KEGG: Kyoto Encyclopedia of Genes and Genomes. Wang J, An Y, Li ZL, et al. XFZY is composed of 11 herbs: peach kernel, safflower, Rehmannia glutinosa, ligusticum chuanxiong, red peony root, radix platycodonis, radix platycodonis, radix bupleurum, bran fried fructus aurantii, licorice, and Angelica sinensis.
A range of liver issues including hepatitis and cirrhosis. XFZYT regulated 12 targets upstream of the PI3K-Akt signaling pathway (hsa04151), such as KDR, VEGFA, and PTK2 and 35 targets downstream, such as Akt3 and CHUK. Chinese J Inform TCM. It has the characteristics of acute onset, rapid change of disease condition, high mortality and disability rate, and is more common in middle-aged and elderly people. Persistent daytime drowsiness. Under no circumstances does. ICH-related pathways can be decomposed into functional modules such as apoptosis, inflammation, and oxidative stress. Selection and verification of CCG. Xue fu zhu yu wan chai. All chemical structures were converted into canonical SMILES by the software Open Babel toolkit (version 2. Salves, Creams & Ointments. Primarily used for blood stasis with wind-damp in the channels and collaterals characterized by internal deficiency with external excesses - joint pain, muscle aches, numbness and/or pain in the lowe…. Participants will self-rate their peak pain intensity using VAS, report menstrual pain duration, and fill out CMSS at baseline and each visit. When patients undergo unbearable pain during menstruation, painkillers (Fendid) will be given according to doctors' orders, and the concomitant medication will be recorded. TCM Database@Taiwan: the world's largest traditional Chinese medicine database for drug screening in silico.
Chengdu: Chengdu University of Chinese medicine; 2017. Health economics will be assessed at baseline and each visit of treatment duration. Continuing Education. The randomization sequence will be strictly confidential and maintained by IBRCM. Showed that NOTCH3 gene mutation may cause cerebral hemorrhage by changing the structure and function of cerebral small vessels [25]. The protocol version is V1. The participants will receive either XFZY or placebo, three times per day, for 3 menstrual cycles, with a 12-week follow-up. As a global company based in the US with operations in other countries, Etsy must comply with economic sanctions and trade restrictions, including, but not limited to, those implemented by the Office of Foreign Assets Control ("OFAC") of the US Department of the Treasury. Uncovering the potential mechanism of Xue Fu Zhu Yu Decoction in the treatment of intracerebral hemorrhage | BMC Complementary Medicine and Therapies | Full Text. BF2019-175-01) and each center. Chronic gum disease with dark, purplish, patchy or dark, red atrophic gums. Blue Poppy Formulations.
We want to conduct a randomized controlled trial to evaluate the efficacy and safety of XFZY for PD patients. Another randomized trial found that compared with fenbid solely, XFZY decoction plus fenbid had a better pain intensity relief [28]. Chapter 8: Assessing risk of bias in included studies. Three ADME-related modules (OB, DL, and Caco-2) were used to screen biologically active compounds.
Besides, abnormal laboratory findings with clinical significance will also be recorded as AEs. Pain and inflammation from acute trauma, generalized aches and pains or mor…. Acacetin, quercetin, luteolin (≥ 98% purity by HPLC) was obtained from Jiangsu Yongjian Biotech Co., Ltd (Chengdu, China). How to find the core functional compound groups in these regulatory networks and analyze the mechanism is one of the key ways for us to understand the mechanism of prescriptions in the treatment of complex diseases. To our knowledge, this is the first clinical study to investigate the efficacy of XFZY for PD compared to a placebo. Heilongjiang Science and Technology Information(19), 106. doi:-. Found that amyloid precursor protein (APP) mutation can cause typical pathological changes of AD and perivascular amyloid deposition [24]. Dysmenorrhea can be classified into primary dysmenorrhea (PD) and secondary dysmenorrhea, with the former more prevalent in young women [2]. Meet the diagnostic criteria for PD and QBP in CM. Post traumatic insomnia. Xue fu zhu yu wan qing. It was found that effective protein enriched pathways covered 88.
2011) determination of 3 compounds of triterpenoid saponins in Platycodon grandiflorum. A single formula, alone, may not be sufficient to fully address a particular TCM diagnostic pattern. Participants in other clinical trials. Self-Rating Anxiety Scale (SAS) ≥ 60 or Self-Rating Depression Scale (SDS) > 62. CRF: Case report form. This study may be limited in that 3 months of treatment duration may be insufficient for complete PD pain relief. Bio-Hazard Sharps Containers. Liniments, Oils and Ointments. Chinese Clinical Trial Registry ChiCTR1900026819. Invigorates blood, dispels stasis (stronger than Mu Dan Pi) - dysmenorrhea, amenorrhea, abdominal pain and masses, traumatic pain associated with swelling, early stages of abscesses and boils. Huang Q, Lan T, Lu J, Zhang H, Zhang D, Lou T, Xu P, Ren J, Zhao D, Sun L, Li X, Wang J. Xue fu zhu yu wan health benefits. DiDang Tang Inhibits Endoplasmic Reticulum Stress-Mediated Apoptosis Induced by Oxygen Glucose Deprivation and Intracerebral Hemorrhage Through Blockade of the GRP78-IRE1/PERK Pathways. This means that Etsy or anyone using our Services cannot take part in transactions that involve designated people, places, or items that originate from certain places, as determined by agencies like OFAC, in addition to trade restrictions imposed by related laws and regulations.
The GPHCM Department of Scientific Research and the Office of National Key Technology R&D Program for the Thirteen Five-year Plan of the Ministry of Science and Technology, China, will inspect the trial. Formulas may be used alone, in combinations, and/or in stages. XFZY promotes Qi and activates the blood to relieve QBP symptoms [12]. These data were merged to construct comprehensive PPI network. And Citrus aurantium L can be used to disperse lung, relieve sore throat, eliminate phlegm and discharge pus; Bupleurum chinense DC can be used to liver stagnation and qi stagnation, chest and rib pain, Glycyrrhiza uralensis Fisch has the efficacy of relieving pain and harmonizing various drugs. 59% in the hypoxia treated cells. In the process of treating complex diseases, Chinese medicine prescriptions usually exert their functional effects according to compatibility principles. Dysmenorrhea is a common gynecological disease. A total of 248 participants with PD will be recruited at 6 centers and randomized into two groups—a herbal treatment group and a placebo group. Xue Fu Zhu Yu Wan | Drive out Stasis in the Mansion of Blood | Modern Herb Shop. Traces of any data modification will be required to be retained.
Cerebral arteriosclerosis. Pulmonary tuberculosis. Statistical analysis. The molecular mechanism of XFZYD in treating ICH was deduced based on CCG and their targets. Trends Pharmacol Sci. The dose may be doubled for a quicker and stronger response as needed (e. g., in an acute phase). Used systematic pharmacology to analyze the synergistic mechanism of LiuWei DiHuang Pill in Type 2 Diabetes Mellitus [12]. For legal advice, please consult a qualified professional.
Chronic prostatitis. In this research, we designed a new node importance calculation method and validated the accuracy and reliability. Pract Clin J Integr Tradit Chin West Med. To remedies that focus on modern concerns such as blood sugar and stress. Dispels blood stasis, alleviates pain - blood sta…. Most of the targets of XFZYT in the regulation of PI3K-Akt signaling pathway are located in the downstream of this pathway, such as Akt3 and PIK3CA. For example, PI3K-Akt signaling pathway (hsa04151) has been reported to be involved in the inhibition of apoptosis, cell proliferation, and expression of inflammatory cytokines. Blood Stagnation of the chest and diaphragm. According to some literatures, PI3K/Akt/mTOR signaling pathway play important roles in cell proliferation and growth.
Before recruitment, investigators, assessors, and research assistants will attend a training workshop to ensure they adhere to the study protocol and are familiar with the administration process. Immune System Support. Physicians of Chinese medicine treat patients according to pattern differentiation. Take 3 grams of powder or capsules 2-3 times a day, or as practitioners recommended. Statistical analysis will be performed by qualified statisticians who are independent from the research team and are blinded to treatment allocation. Nonsteroidal anti-inflammatory drugs for dysmenorrhoea.
Wang YJ, Li ZX, Gu HQ, Zhai Q, Zhao JZ. It will be conducted in 6 university hospitals in different Chinese provinces. Thus, we assumed that the mean change in VAS should be 3. Chemical identification is the critical step to clarify the material basis and action mechanism of prescription. Found that ESR2 was significantly related to the risk of stroke [41]. 94 (mean ± SD) [34].