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The first level of design is to construct the optimization space based on the node importance calculation method, and verify that the information of disease-related genes will be preserved as much as possible in this step as the core protein or functional protein in the optimization space. Cumulative painkiller consumption. Xue fu zhu yu wan while trying to conceive?. In a previous trial, the mean change for VAS in the placebo group was 0. XFZYT may activate the downstream PI3K and AKT proteins through the upstream KDR, resulting in the cascade amplification of downstream PIK3CA, Akt3, and GSK3B, which is closely related to ICH cell proliferation and protein synthesis. Qi and blood stagnation in the lower jiao - lower abdominal masses, fibroids, ovarian cysts, endometriosis. XFZY is a modified dosage of Xuefu Zhuyu Decoction, and the treatment in Chou's study was added or subtracted on the basis of the pattern. All herbal and homeopathic products sold by Acu-Market.
Thus, we assumed that the mean change in VAS should be 3. Therefore, ICH lymphocytes accumulate towards apoptosis or proliferation in S phase and G2/M phase. Under no circumstances does. Aged 18 to 35 years. Invigorates Blood, regulates Qi and alleviates pain. The results showed that the coverage rates of the three enriched pathways were 87. CHINESE JOURNAL OF INFORMATION ON TRADITIONAL CHINESE MEDICINE(08), 52–54. CHM: Traditional Chinese medicine. Showed that 5-lipoxygenase (5-LO) activator protein (FLAP) was encoded and synthesized by ALOX5AP gene, which was necessary for 5-LO activation and leukotriene synthesis [42]. KEGG: Kyoto Encyclopedia of Genes and Genomes. Frequency differences for AEs and ADRs will be compared with a chi-square test or Fisher's exact test. Uncovering the potential mechanism of Xue Fu Zhu Yu Decoction in the treatment of intracerebral hemorrhage | BMC Complementary Medicine and Therapies | Full Text. The CHM formula Xuefu Zhuyu (XFZY) has been widely used in clinical in China [13] and was the most frequently used in research focused on blood stasis in Korea [14]. Blue Poppy Granule Singles.
Plasters (Gao) and Patches. Nonsteroidal anti-inflammatory drugs for dysmenorrhoea. These include indigestion, headaches, and drowsiness [6]. 445 effective proteins were identified from the effective space. ClusterProfiler: an R package for comparing biological themes among gene clusters. Chronic glomerulonephritis. Moxa Extinguishers & Lighters. Xue Fu Zhu Yu Wan, Herbal Times®. Dysmenorrhea is a common gynecological disease. Huang Q, Lan T, Lu J, Zhang H, Zhang D, Lou T, Xu P, Ren J, Zhao D, Sun L, Li X, Wang J. DiDang Tang Inhibits Endoplasmic Reticulum Stress-Mediated Apoptosis Induced by Oxygen Glucose Deprivation and Intracerebral Hemorrhage Through Blockade of the GRP78-IRE1/PERK Pathways. Pain visual analog scale (VAS) score > 4. Here, a novel integrated pharmacology module was designed to predict the CCG and depict the underlying mechanisms of XFZYD on ICH (Fig. Cotton & Paper Products. Experimental study of Xuefu Zhuyu decoction in activating blood and removing blood stasis.
Effects of Xuefu Zhuyu Decoction on Serum Asymmetric Dimethylarginine in Atherosclerosis Rats. Intracerebral Hemorrhage (ICH). Gfeller, D., Grosdidier, A., Wirth, M., Daina, A., Michielin, O., & Zoete, V. (2014). Prevalence and risk factors associated with primary dysmenorrhea among Chinese Female University students: a cross-sectional study. Huiling D. The research of the distribution of TCM constitution and TCM syndrome and the correlation factors of primary dysmenorrhea patients. Are not meant to treat, cure or prevent disease. Nei Mong J Tradit Chin Med. The economic sanctions and trade restrictions that apply to your use of the Services are subject to change, so members should check sanctions resources regularly. Xue fu zhu yu pian. Compared with control group, the effect of cell viability was significantly decreased by 32. Some other trials also found XFZY had a better response rate for PD as compared to conventional medication (e. g., diclofenac sodium, ibuprofen) with head-to-head comparison [23, 24, 25] or add-on design [26, 27].
An experimental study on the effect of Xuefu Zhuyu pills on activating qi and removing blood stasis. Consult your practitioner for precise dosage recommendations based on body weight and other factors. These results fully proved the accuracy and reliability of our computational model for screening key compound groups based on the optimization space. Lin JM, Zhou HT, Zheng LP, Zhou JH, Zhao JY, Zhuang QC, Wang RG. Leem J, Jo J, Kwon CY, et al. Intercostal neuralgia. SwissTargetPrediction: a web server for target prediction of bioactive small molecules. Clinical study on primary dysmenorrhea treated with combination of traditional Chinese medicine and Western medicine. Through network topology analysis, it is found that APP, SRC, MAPK1 and other genes have higher degrees. The DSMC will be established before the trial in order to monitor the safety events throughout. Xue fu zhu yu wan treatment. We analyzed the function of XFZYD in the treatment of ICH base on the KEGG enriched pathways of CCG targets and ICH pathogenic genes. Cell culture and oxygen–glucose deprivation (ogd) treatment. Chinese Journal of Hospital Pharmacy(12), 1080–1082.
Guang C. Efficacy and full transcriptome mechanism of medicine for qi stagnation and blood stasis syndromes. Biochem Biophys Res Commun. XFZYD composed of these herbs has the effects of eliminating edema and improving local circulation, so it is widely used in the treatment of ICH. The higher the percentage, the higher the reliability and accuracy of the model. This product is not intended to diagnose, treat, cure or prevent any disease. Moreover, most of the previous trials appeared to be of low methodological quality. Non-steroidal anti-inflammatory drugs (NSAIDs) are an effective treatment for PD [5, 6], but can cause adverse events in the gastrointestinal tract and central nervous system [7]. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Xue Fu Zhu Yu Wan | Drive out Stasis in the Mansion of Blood | Modern Herb Shop. He H, Chen G, Gao J, et al. Regulates and harmonizes the other herbs. A flow chart of this trial is provided in Fig. This policy is a part of our Terms of Use.
Besides, abnormal laboratory findings with clinical significance will also be recorded as AEs. Pain of all types from qi and blood stagnation - often combined with other more systemic formulas based on the individual. The first category of making a table is the direct interaction between pathogenic genes and compounds targets. Activation of AKT can induce the phosphorylation of lipid substrate and can promote downstream protein kinase B, which can contribute to cell proliferation and differentiation [45]. Downstream targets account for more than 70%. Outpatient clinical staff will also screen and refer potential patients who will then access the study information. Among them, PI3K-Akt signaling pathway (hsa04151) is one of the main pathways for XFZYT to treat ICH. Therefore, how to promote hematoma absorption as soon as possible and reduce edema around the blood clots are a difficult point in conservative treatment. For secondary outcomes, continuous and categorical data will be compared between the two groups with either a t test, chi-square test or Fisher's exact test. Bio-Hazard Sharps Containers. HT22 cells were cultured in DMEM with 10% FBS, and incubated at 37 °C under 5% CO2. Chin J Neurotraumatic Surg (Electronic Edition). A proprietary blend of: Semen Pruni Persicae (Tao Ren), Flos Carthami Tinctorii (Hong Hua), Rhizoma Ligustici Chuanxiong (Chuan Xiong), Radix Angelicae Sinensis (Dang Gui), Radix Achyranthis Bidentatae (Niu Xi), Fructus Aurantii (Zhi Qiao), Radix Paeoniae Rubra (Chi Shao), Radix Platycodi Grandiflori (Jie Geng), Radix Bupleuri Chinensis (Chai Hu), Radix Rehmanniae Glutinosae (Di Huang), Radix Glycyrrhizae Uralensis (Gan Cao). In the first step, all XFZYD compounds were extracted from database and literatures.
With Chi Shao, invigorates Blood primarily in the lower body and nourishes and moistens Dryness. Prostatic hypertrophy. Higher OB usually is an important indicator to determine the drug-like property of biologically molecules as therapeutic drugs. The differences were analyzed by one-way ANOVA for multiple comparisons, and Student's t test was utilized to compare the significance of differences between two groups. The placebo's primary ingredients are honey, white granulated sugar, fried brown sugar, bitterants, ginseng essence, natural edible pigments, and food antiseptic.
Studies have shown that PI3K is an important phosphatidylinositol kinase, which involve in cell growth and bone remodeling, and is an important anti-apoptosis regulator. Draghici S, Khatri P, Tarca AL, Amin K, Done A, Voichita C, Georgescu C, Romero R. A systems biology approach for pathway level analysis. Wu Y, Huai J, Zhou P. Determination of five components in Safflower.