His writing and reporting have also appeared in the New York Times, The Atlantic, Oxford American, and The New York Review of Books. As Keefe tells Inverse: "One of the biggest choices I made in writing the book was to devote almost a third of the book to the life of the guy who dies before OxyContin. Working at a barbaric mental institution, Arthur saw a better way and conducted groundbreaking research into drug treatments. But I also get a lot of notes from chronic pain patients who say, "Please stop writing these articles or in this book; you are making it harder for me to access the medicine that I rely on. Eventually, he purchased Purdue for them to run. "Empire of Pain reads like a real-life thriller, a page-turner, a deeply shocking dissection of avarice and calculated callousness… It is the measure of great and fearless investigative writing that it achieves retribution where the law could not….
Where do you think it took a hard left turn? PATRICK RADDEN KEEFE is a staff writer at The New Yorker and the author, most recently, of the New York Times bestseller Say Nothing: A True Story of Murder and Memory in Northern Ireland, which received the National Book Critics Circle Award for Nonfiction, was selected as one of the ten best books of 2019 by The New York Times Book Review, The Washington Post, Chicago Tribune and The Wall Street Journal, and was named one of the top ten nonfiction books of the decade by Entertainment Weekly. What for you, personally, was the most striking thing to emerge from the documents you found? "A shocking saga… [a]tour-de-force account… [Keefe] brings to life the obsessive personalities and ferocious energy of some members…The Sacklers emerge as a shameless bunch, but Empire of Pain also poses troubling questions about the US healthcare system that permitted them to flourish. " It was one of my favorites from this whole past year.
He promoted the practice of having drug companies cite doctor-approved studies about how well the drug worked, studies that had often been sponsored by the companies themselves. It's an altogether damning detailed and vividly written. During the bankruptcy hearings, several family members of the deceased tried to speak, apparently hoping for closure. A central problem for generations was that the most effective drugs were prone to cause addiction. Thank you to all who joined us on May 11th for our very special evening with award-winning author Patrick Radden Keefe as he discussed his newest book, Empire of Pain: The Secret History of the Sackler Dynasty, with New Yorker writer Jonathan Blitzer. And I really, really, really wanted to find out more about his life, but it was very hard. They continued to supply providers who, Keefe writes, the company knew from its sales data were almost certainly overprescribing. AB: Yeah, the thing that I couldn't wrap my head around was how much obfuscation there was and how privacy is part and parcel of the Sackler family. And although they were less academically accomplished than Arthur, they shared their brother's fascination with pharmacology.
The family had, he told McLean, been "giving where our hearts are" and he very much hoped the leadership at Yale, Harvard, and the Victoria and Albert would have a "change of heart. Instead, he writes, company officials saw the penalties as a "speeding ticket. " But Isaac and Sophie had dreams for Arthur and his brothers, dreams that stretched beyond Flatbush, beyond even Brooklyn. Book Club Recommendations. It's the story of amoral capitalism, a story of a national business culture that puts greed and profit above all else, and a story about a political culture in which moral judgements can be set off to the side when ambition takes centerstage. I find that it is helpful to just ground the reporting. And the fascinating thing is they succeeded. The answer: "There is no evidence low-skilled migration to rich countries drives wage and employment down for the natives. " RADDEN KEEFE: I think this is a family that's very deep in denial. In "Empire of Pain, " Keefe marshals a large pile of evidence and deploys it with prosecutorial precision. If I had to pick one, I'd throw out Richard Kapit, who was Richard Sackler's college roommate.
It's not likely to flip-flop anyone's opinion over who is to blame for the addiction epidemic: If you've made it this far with your belief of the Sacklers' innocence intact, there's likely nothing that can be said to sway you. I was just struck by so many of the resonances between the rollout of OxyContin and everything Arthur was doing in the 1950s and 1960s with Valium. The decisions that birthed and perpetuated the epidemic were not made by employees or a management team, he reveals, but by members of this cultured clan of physicians, long acclaimed for their arts philanthropy... As Keefe ably demonstrates, it was the Sacklers who dreamed up OxyContin as a solution to an anticipated revenue decline, and it was the Sacklers who insisted their powerful narcotic, the sort of drug previously reserved for terminal patients, be marketed aggressively and widely... REQUEST DISCUSSION QUESTIONS. And then in parallel to that was a lot of hunting through documents. Arthur was a genius — a fascinating, protean figure who revolutionized pharmaceutical marketing in the 1950s and 1960s. We know what you're thinking: I've heard this story before. Where it's the opposite extreme, where you have a marginalized, stigmatized, often vilified kind of person. And as they (the pharma companies) release their full documention we see the laundry list of side effects. Twice as powerful as morphine, OxyContin was developed and patented by Purdue and aimed at anyone who suffered from pain. The rest comes from Keefe's own reporting, which included interviews with more than 200 people, access to internal company documents, and a review of tens of thousands of pages of court documents that public and private lawyers collected in the course of their investigations and lawsuits. Avid Using scientific principles to develop pharmaceuticals is not a criminal enterprise.
So, I picked up and re-read Frank Cottrell Boyce's endearing novel Millions. There are other forces, and there's the trend of pain management growing at the same time. Arthur didn't invent this phenomenon, but he really excelled at it. But he insisted that he had not given his children nothing. Some of the material comes from other journalists — among them Barry Meier, author of the acclaimed 2003 book "Pain Killer: A 'Wonder' Drug's Trail of Addiction and Death, " who is also a key character in Keefe's story. In what they call a "slightly technical aside, " they build a case for addressing trade issues not with trade wars but with consumption taxes: "It makes no sense to ask agricultural workers to lose their jobs just so steelworkers can keep theirs, which is what tariffs accomplish. "
And there are a lot of doctors who are criminal doctors, many of whom went to prison. And obviously, greed does play a really significant role in the story, but I also think idealism is part of this. He writes about an immigrant Jewish couple in Brooklyn who gave birth to three brothers — Arthur, Mortimer and Raymond. He intended to charge Friedman, Goldenheim, and Udell with the crimes of money laundering, wire fraud, and mail fraud. I was sick and tired — and more than a bit bored — of spending so much time with the self-important, amoral and insanely rich Sackler family. "Arthur invented the wheel, " as one former employee at the advertising agency put it.
There's lots of evidence that children over the years had used and, in some cases, died from the drug. Over the past few years we have focused on discussing memoirs, biographies, and other works of nonfiction. But if Arthur made his first fortune from the questionable marketing of Valium, his brothers went on to make an even larger one by employing those tactics to sell a drug called OxyContin. And so it was that the Sackler name became prominent in the Louvre, the Tate, the Metropolitan and the Guggenheim galleries, as well as at Yale, Harvard and Oxford universities and a number of medical schools. Keefe turns up plenty of answers, including the details of how the Sacklers—the first generation of three brothers, followed by their children and grandchildren—marketed their goods, beginning with "ethical drugs" (as distinct from illegal ones) to treat mental illness, Librium and then Valium, which were effectively the same thing but were advertised as treating different maladies: "If Librium was the cure for 'anxiety, ' Valium should be prescribed for 'psychic tension. ' Thousands of court documents have become public through discovery, including internal company emails and memos that give new insight into the family's actions and thinking.
This is what separates them from legitimate pharmaceutical companies who respond to scientific feedback in appropriate ways. When eventually, under public pressure, the government caught up with Purdue, the company filed for bankruptcy and, protected by some of the best lawyers in the business, the Sacklers walked free of any criminal charges, still adamant they had done nothing wrong. The series offers catharsis for the viewer. Like many children of immigrants, their dreams involved getting a good education and working hard to build their fortunes. RADDEN KEEFE:.. they met with doctors. The drug went on to generate some thirty-five billion dollars in revenue, and to launch a public health crisis in which hundreds of thousands would die.
He delivered flowers. It's all about over-marketing. He was descended from a line of rabbis who had fled Spain for central Europe during the Inquisition, and now he and his young bride would build a new beachhead in New York. That kind of journalism remains the reason why even the greatest of fortunes can't buy the one thing its heirs want most: secrecy. Loved the 'interview' format. Nor was he content with the one job. AB: Oh my god, how frustrating. You feel almost guilty for enjoying it so much. " Curtis Wright, the FDA official responsible for approving OxyContin, went to work for the company right after leaving public service.
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